Popular Cardiologist in Bettahalasur, Bangalore Thrombogenic factors Thrombosis is an important pathological process in coronary artery disease. Factors increasing the tendency to thrombosis include: smoking hypertriglyceridaemia nelevated fibrinogen (possibly) n oestrogen-containing contraceptive pills n polycythaemia n increased von Willebrand factor (a marker of endothelial dysfunction). The following factors are associated with reduced thrombotic tendency: low-dose aspirin other anti-platelet drugs (e.g. clopidogrel) fish oils and mono-unsaturated fatty acids. Alcohol intake