Multi-Vessel Vasospastic Angina Is Associated With Poor Cardiovascular Outcomes A study was performed to compare the prognosis of multi-vessel VSA with single vessel VSA. The study included 2960 patients; out of them, 163 patients had single vessel VSA, 104 patients had multi-vessel VSA, and 737 patients had non-VSA. The baseline characteristics and medical treatment on discharge were similar between multi-vessel VSA and single vessel VSA groups but was different for the non-VSA group. Cardiac death, symptomatic new-onset arrhythmia, and acute coronary syndrome were the primary composite endpoint. The follow-up duration was for 36-months. It was found that the primary composite endpoint was significantly higher in the multi-vessel VSA group (8.7%) as compared to single-vessel VSA and non-VSA groups (1.8% and 1.1% respectively). Multi-vessel VSA group (5.8%) had a higher rate of death and acute coronary syndrome as compared to the single vessel VSA and non-VSA groups (1.2% and 0.9%, respectively). Moreover, the multi-vessel VSA was an independent predictor of the primary composite endpoint at the end of 36 months. The study results manifested that patients with multi-vessel VSA had poor outcomes as compared to the single vessel VSA and non-VSA groups. Thus, the presence of multi-vessel VSA itself was highly prognostic.