best doctors near me Liver enlargement, also known as hepatomegaly, can be caused by a variety of conditions. Some common causes include: Infections: Viral hepatitis (Hepatitis A, B, C), mononucleosis, and liver abscesses. Alcohol-related liver disease: Long-term alcohol consumption can lead to conditions like alcoholic hepatitis or cirrhosis, causing liver enlargement. Fatty liver disease: This can be non-alcoholic fatty liver disease (NAFLD) or alcohol-induced fatty liver. NAFLD is linked to obesity, diabetes, and high cholesterol. Heart failure: Chronic heart failure can cause blood to back up into the liver, leading to enlargement (congestive hepatopathy).